Integrins Anchor the Invasive Machinery

Integrins anchor the invasive machinery.

Cell invasion through the basement membrane, a process important for both development and disease pathogenesis, depends on an interplay of adhesive, force transducing, proteolytic, and chemotactic machineries. The mechanisms whereby these different processes are integrated on the cellular level have remained elusive. In this issue of Developmental Cell, Sherwood and coworkers now identify integ...

Integrins in invasive growth.

Integrins in invasive growth

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An ex(o)citing machinery for invasive tumor growth.

Cancer cells communicate with the environment through delivery of surface proteins, release of soluble factors (growth factors and cytokines), and sophisticated nanovehicles (exosomes) for establishment of invasive tumor growth. This communication occurs in part through constitutive exocytosis, regulated exocytosis, or release of intraluminal vesicles, and is modulated by small Rab GTPases, the...

Chaotic Hybrid Invasive Weed Optimization for Machinery Optimizing

We present a chaotic hybrid invasive weed optimization (CHIWO) algorithm with an adaptive penalty function which is introduced to solve the constraints for solving the machinery optimizing problems. The proposed CHIWO algorithm runs consistently well on the studies of 13 Benchmark functions and 3 machinery optimizing problems. Experimental results indicate that CHIWO algorithm is a simple and e...